Mapping determinants of human gene expression by regional and genome-wide association

@article{Cheung2005MappingDO,
  title={Mapping determinants of human gene expression by regional and genome-wide association},
  author={Vivian G. Cheung and R. S. Spielman and Kathryn Gogolin Ewens and Teresa M. Weber and Michael Morley and Joshua T. Burdick},
  journal={Nature},
  year={2005},
  volume={437},
  pages={1365-1369}
}
To study the genetic basis of natural variation in gene expression, we previously carried out genome-wide linkage analysis and mapped the determinants of ∼1,000 expression phenotypes. In the present study, we carried out association analysis with dense sets of single-nucleotide polymorphism (SNP) markers from the International HapMap Project. For 374 phenotypes, the association study was performed with markers only from regions with strong linkage evidence; these regions all mapped close to the… CONTINUE READING
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Genetic analysis of genome-wide variation in human gene expression

  • M Morley
  • Nature 430,
  • 2004

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