Mapping determinants of human gene expression by regional and genome-wide association

  title={Mapping determinants of human gene expression by regional and genome-wide association},
  author={Vivian G. Cheung and R. S. Spielman and Kathryn Gogolin Ewens and Teresa M. Weber and Michael Morley and Joshua T. Burdick},
To study the genetic basis of natural variation in gene expression, we previously carried out genome-wide linkage analysis and mapped the determinants of ∼1,000 expression phenotypes. In the present study, we carried out association analysis with dense sets of single-nucleotide polymorphism (SNP) markers from the International HapMap Project. For 374 phenotypes, the association study was performed with markers only from regions with strong linkage evidence; these regions all mapped close to the… CONTINUE READING
Highly Influential
This paper has highly influenced 27 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
356 Citations
24 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 356 extracted citations


Publications referenced by this paper.
Showing 1-10 of 24 references

Genetic analysis of genome-wide variation in human gene expression

  • M Morley
  • Nature 430,
  • 2004

Similar Papers

Loading similar papers…