Mapping critical sites in collagen II for rational design of gene-engineered proteins for cell-supporting materials.

@article{Fertala2001MappingCS,
  title={Mapping critical sites in collagen II for rational design of gene-engineered proteins for cell-supporting materials.},
  author={Andrzej Fertala and Wang Bao Han and Frank K. Ko},
  journal={Journal of biomedical materials research},
  year={2001},
  volume={57 1},
  pages={48-58}
}
Collagen II is the most abundant protein of cartilage and forms a network of fibrils extended by proteoglycans that enables cartilage to resist pressure. The surface of the collagen fibril serves as a platform for the attachment of collagen IX, growth factors, and cells. In this study we examined the mechanism of the interaction of chondrocytes with recombinant versions of procollagen II, in which one of the four blocks of 234 amino acids that define repeating D periods of the collagen triple… CONTINUE READING

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