Mapping cortical change across the human life span

  title={Mapping cortical change across the human life span},
  author={Elizabeth R. Sowell and Bradley S. Peterson and Paul M. Thompson and Suzanne E. Welcome and Amy L. Henkenius and Arthur W. Toga},
  journal={Nature Neuroscience},
Key MethodWe used magnetic resonance imaging and cortical matching algorithms to map gray matter density (GMD) in 176 normal individuals ranging in age from 7 to 87 years. We found a significant, nonlinear decline in GMD with age, which was most rapid between 7 and about 60 years, over dorsal frontal and parietal association cortices on both the lateral and interhemispheric surfaces. Age effects were inverted in the left posterior temporal region, where GMD gain continued up to age 30 and then rapidly…
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  • N. Gogtay, J. Giedd, P. Thompson
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
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