Mapping apolipoprotein B on the low density lipoprotein surface by immunoelectron microscopy.

@article{Chatterton1991MappingAB,
  title={Mapping apolipoprotein B on the low density lipoprotein surface by immunoelectron microscopy.},
  author={Jon E. Chatterton and Martin L. Phillips and Linda K. Curtiss and Ross W. Milne and Yves L. Marcel and Verne N. Schumaker},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 9},
  pages={5955-62}
}
Apolipoprotein B (apoB) was mapped using electron microscopy to visualize pairs of monoclonal antibodies binding to the low density lipoprotein (LDL) surface. The sites at which these monoclonals bind the apoB polypeptide sequence had already been established. The angular distances between all possible pairs of binding sites except one allowed the relative placement of six epitopes on the LDL sphere. We conclude that apoB extends over at least a hemisphere of the LDL surface since four epitopes… CONTINUE READING
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