Mapping and characterization of transcriptional pause sites in the early genetic region of bacteriophage T7.

@article{Levin1987MappingAC,
  title={Mapping and characterization of transcriptional pause sites in the early genetic region of bacteriophage T7.},
  author={Judith R Levin and Michael J. Chamberlin},
  journal={Journal of molecular biology},
  year={1987},
  volume={196 1},
  pages={61-84}
}
During transcription of DNA templates in vitro, Escherichia coli RNA polymerase pauses at certain sequences before resuming elongation. Previous studies have established that some pausing events are brought about by the formation of RNA hairpin structures in the nascent transcript; however, it is not known whether this is an invariant and causal relationship. We have mapped and characterized almost 200 distinct pause sites located within the early region of bacteriophage T7 DNA using a… CONTINUE READING

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