Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9.

@article{Robertson1997MappingAC,
  title={Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9.},
  author={Nahid G. Robertson and Anne B. Skvorak and Yan-hui Yin and Stanislawa Weremowicz and Kenneth R. Johnson and K A Kovatch and James F. Battey and Frederick R. Bieber and Cynthia C Morton},
  journal={Genomics},
  year={1997},
  volume={46 3},
  pages={345-54}
}
Previously we identified a partial human cDNA for a novel cochlear transcript, hCoch-5B2 (HGMW-approved symbol D14S564E), using subtractive hybridization techniques. Herein we report isolation and characterization of both human and mouse (D12H14S564E) cDNAs for Coch-5B2. Full-length Coch5B2 deduced amino acid sequences reveal a very high degree of conservation in the coding region (89% nucleotide and 94% amino acid identity and a potential signal peptide and two regions of extensive homology to… CONTINUE READING
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