Mapping Symptoms to Brain Networks with the Human Connectome.

  title={Mapping Symptoms to Brain Networks with the Human Connectome.},
  author={Michael D. Fox},
  journal={The New England journal of medicine},
  volume={379 23},
  • M. Fox
  • Published 6 December 2018
  • Psychology, Medicine
  • The New England journal of medicine
The Brain Connectome and New Methods of Lesion Analysis Complex neurologic and psychiatric syndromes cannot be understood on the basis of focal brain lesions. Functional neuroimaging, maps of inter... 

Figures from this paper

Atrophy network mapping of transdiagnostic cognitive and neuropsychiatric symptoms.

  • M. Veldsman
  • Psychology
    Brain : a journal of neurology
  • 2020
This scientific commentary refers to ‘Network localization of clinical, cognitive, and neuropsychiatric symptoms in Alzheimer’s disease’, by Tetreault etal. (doi:10.1093/brain/awaa058).

Neuroimaging in Parkinson’s disease dementia: connecting the dots

Findings in Parkinson’s dementia localise to a common brain network centred on the hippocampus, making sense of an otherwise discordant neuroimaging literature, lending insight into Parkinson's dementia.

Mapping holmes tremor circuit using the human brain connectome

It is tested whether lesion locations that cause Holmes tremor map to a connected brain circuit and whether this circuit might serve as a useful therapeutic target.

Structural brain disconnectivity mapping of post-stroke fatigue

Network Effects of Brain Lesions Causing Central Poststroke Pain

This study was undertaken to test whether lesions causing central poststroke pain (CPSP) are associated with a specific connectivity profile, whether these connections are associated with metabolic

Bridging structural and functional biomarkers in functional movement disorder using network mapping

There are gaps in the neurobiological understanding of functional movement disorder (FMD), and research is needed to bridge these gaps.

Structural disconnectome mapping of cognitive function in poststroke patients

Sequalae following stroke represents a significant challenge in current rehabilitation and one explanation building on recent work on brain networks proposes that the cognitive consequences of focal lesions are caused by damages to anatomically distributed brain networks supporting cognition rather than specific lesion locations.

Mapping a memory disorder using functional network analysis

  • B. Edlow
  • Psychology, Biology
    Acta neurologica Scandinavica
  • 2021
A networkbased brain mapping study of transient global amnesia (TGA), providing groundbreaking new insights into this rare amnestic syndrome characterized by an acute, transient loss of shortterm memory and suggesting that networkbased measures of brain connectivity may provide insights into TGA pathophysiology and recurrence risk that cannot be derived from conventional measures of regional CBF.



Human brain lesion-deficit inference remapped

Mah et al. show that the established methodology for conducting voxel-wise mass univariate inference mislocalises function owing to complex correlations in natural patterns of damage across the brain; a problem soluble only by high-dimensional multivariate inference.

Human Lesion Studies in the 21st Century

Images of psychopathology

Connectivity Predicts deep brain stimulation outcome in Parkinson disease

The structural and functional connectivity profile of effective DBS to the subthalamic nucleus (STN) is identified and its ability to predict outcome in an independent cohort is tested.

Lesions causing freezing of gait localize to a cerebellar functional network

Brain lesions causing acute onset freezing of gait are analyzed to identify regions causally involved in symptom generation.

Corticospinal tract lesion load: An imaging biomarker for stroke motor outcomes

The aim of this work was to investigate whether an imaging measure of corticospinal tract (CST) injury in the acute phase can predict motor outcome at 3 months in comparison to clinical assessment of

A disconnection account of Gerstmann syndrome: Functional neuroanatomy evidence

To examine the functional neuroanatomy that could account for pure Gerstmann syndrome, which is the selective association of acalculia, finger agnosia, left‐right disorientation, and agraphia.

The connectomics of brain disorders

This work considers how brain-network topology shapes neural responses to damage, highlighting key maladaptive processes and the resources and processes that enable adaptation, and shows how knowledge of network topology allows for predictive models of the spread and functional consequences of brain disease.

Network localization of neurological symptoms from focal brain lesions.

The results suggest that heterogeneous lesions producing similar symptoms share functional connectivity to specific brain regions involved in symptom expression and publically available human connectome data can be used to incorporate these network effects into traditional lesion mapping approaches.