Mapping Hsp47 binding site(s) using CNBr peptides derived from type I and type II collagen.

@article{Thomson2003MappingHB,
  title={Mapping Hsp47 binding site(s) using CNBr peptides derived from type I and type II collagen.},
  author={Christy A. Thomson and Ruggero Tenni and Vettai S. Ananthanarayanan},
  journal={Protein science : a publication of the Protein Society},
  year={2003},
  volume={12 8},
  pages={1792-800}
}
As a crucial molecular chaperone in collagen biosynthesis, Hsp47 interacts with the nascent form as well as the mature triple-helical form of procollagen. The location(s) of Hsp47 binding sites on the collagen molecule are, as yet, unknown. We have examined the substrate specificity of Hsp47 in vitro using well-characterized CNBr peptide fragments of type I… CONTINUE READING