Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability

@inproceedings{Nelson2016MappingHO,
  title={Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability},
  author={D. Michael Nelson and Farah Jaber-Hijazi and John J. Cole and Neil Robertson and Jeffrey Scott Pawlikowski and Kevin T. Norris and Steven W. Criscione and Nikolay A. Pchelintsev and Desiree Piscitello and Nicholas Stong and Taranjit Singh Rai and Tony McBryan and Gabriel L. Otte and Colin Nixon and William Henry Clark and Harold Riethman and Hong Wu and Gunnar Schotta and Benjamin A Garcia and Nicola Neretti and Duncan M Baird and Shelley L Berger and Peter David Adams},
  booktitle={Genome Biology},
  year={2016}
}
BackgroundHistone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear, although H4K20me3 abundance increases during cellular senescence, a stable proliferation arrest and tumor suppressor process, triggered by diverse molecular cues, including activated oncogenes. Here, we investigate the function of H4K20me3 in senescence and tumor suppression.ResultsUsing immunofluorescence and ChIP-seq we determine… CONTINUE READING
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