Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.

@article{Winter2017MappingCT,
  title={Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.},
  author={Jean M. Winter and Derek E. Gildea and Jonathan Andreas and Daniel M. Gatti and Kendra A. Williams and Minnkyong Lee and Ying Hu and Suiyuan Zhang and James C. Mullikin and Tyra G. Wolfsberg and Shannon K. McDonnell and Zachary C. Fogarty and Melissa C. Larson and Amy J. French and Daniel J. Schaid and Stephen N. Thibodeau and Gary A. Churchill and Nigel P. S. Crawford},
  journal={Cell systems},
  year={2017},
  volume={4 1},
  pages={
          31-45.e6
        }
}
It is unclear how standing genetic variation affects the prognosis of prostate cancer patients. To provide one controlled answer to this problem, we crossed a dominant, penetrant mouse model of prostate cancer to Diversity Outbred mice, a collection of animals that carries over 40 million SNPs. Integration of disease phenotype and SNP variation data in 493 F1 males identified a metastasis modifier locus on Chromosome 8 (LOD = 8.42); further analysis identified the genes Rwdd4, Cenpu, and Casp3… Expand
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