Mapping 'partially resistant', 'fully resistant', and 'super resistant' malaria.

@article{Naidoo2013MappingR,
  title={Mapping 'partially resistant', 'fully resistant', and 'super resistant' malaria.},
  author={Inbarani Naidoo and Cally Roper},
  journal={Trends in parasitology},
  year={2013},
  volume={29 10},
  pages={505-15}
}
Sulfadoxine-pyrimethamine (SP) is used throughout Africa for intermittent preventive treatment (IPT) of malaria, but resistance threatens its efficacy. We found marked regional differences in the genotypes responsible for SP resistance when mapping recent surveys of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations. In West Africa, a 'partially resistant' combination of dhfr N51I, N59R, and S108N with dhps A437G predominates, whereas in East Africa the 'fully… CONTINUE READING
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