Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.

@article{OKeefe1998MappingGO,
  title={Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.},
  author={Denise S O'Keefe and Sai L. Su and Dean J. Bacich and Yasuhiro Horiguchi and Yan Luo and Charles T. Powell and D W Zandvliet and Peter J. Russell and Peter L Molloy and Norma J. Nowak and T. B. Shows and Charles E. Mullins and R A Vonder Haar and William R. Fair and Warren D. W. Heston},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1443 1-2},
  pages={
          113-27
        }
}
Prostate-specific membrane antigen (PSMA) is a 100 kDa type II transmembrane protein with folate hydrolase and NAALAdase activity. PSMA is highly expressed in prostate cancer and the vasculature of most solid tumors, and is currently the target of a number of diagnostic and therapeutic strategies. PSMA is also expressed in the brain, and is involved in conversion of the major neurotransmitter NAAG (N-acetyl-aspartyl glutamate) to NAA and free glutamate, the levels of which are disrupted in… CONTINUE READING

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