Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice.

@article{Wang2007MappingGI,
  title={Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice.},
  author={Susanna S. Wang and W Shi and Xuping Wang and Leandra Velky and Sarah Greenlee and Min Wang and Thomas A. Drake and Aldons J. Lusis},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 12},
  pages={2671-6}
}
OBJECTIVE C3H/HeJ (C3H) mice are extremely resistant to atherosclerosis. To identify the genetic factors involved in lesion initiation, we studied a cross between C3H and the susceptible strain C57BL/6J (B6) on a hyperlipidemic (apolipoprotein E-null) background. METHODS AND RESULTS Whereas a previous cross in mice fed a Western diet for 16 weeks revealed a very complex inheritance pattern with many significant lesion QTLs, the present cross, on a chow diet, revealed a single major locus on… CONTINUE READING
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