Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling.

  title={Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling.},
  author={Laura V. Danai and Adilson Guilherme and Kalyani V.P. Guntur and Juerg R. Straubhaar and Sarah M. C. Nicoloro and M. Czech},
  journal={Journal of lipid research},
  volume={54 10},
Adipose tissue lipogenesis is paradoxically impaired in human obesity, promoting ectopic triglyceride (TG) deposition, lipotoxicity, and insulin resistance. We previously identified mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), a sterile 20 protein kinase reported to be upstream of c-Jun NH2-terminal kinase (JNK) signaling, as a novel negative regulator of insulin-stimulated glucose transport in adipocytes. Using full-genome microarray analysis we uncovered a novel role for… CONTINUE READING


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