Many roads to maturity: microRNA biogenesis pathways and their regulation

  title={Many roads to maturity: microRNA biogenesis pathways and their regulation},
  author={Julia Winter and S. Jung and S. Keller and Richard I. Gregory and Sven Diederichs},
  journal={Nature Cell Biology},
  • Julia Winter, S. Jung, +2 authors Sven Diederichs
  • Published 2009
  • Medicine, Biology
  • Nature Cell Biology
  • MicroRNAs are important regulators of gene expression that control both physiological and pathological processes such as development and cancer. Although their mode of action has attracted great attention, the principles governing their expression and activity are only beginning to emerge. Recent studies have introduced a paradigm shift in our understanding of the microRNA biogenesis pathway, which was previously believed to be universal to all microRNAs. Maturation steps specific to individual… CONTINUE READING

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