Many faces of NF-kappaB signaling induced by genotoxic stress.

  title={Many faces of NF-kappaB signaling induced by genotoxic stress.},
  author={Zhao-hui Wu and Shigeki Miyamoto},
  journal={Journal of molecular medicine},
  volume={85 11},
The nuclear factor-kappaB (NF-kappaB) family of dimeric transcription factors plays pivotal roles in physiologic and pathologic processes, including immune and inflammatory responses and development and progression of various human cancers. Inactive NF-kappaB dimers normally exist in the cytoplasm in association with inhibitor proteins belonging to the inhibitor of NF-kappaB (IkappaB) family of related proteins. Activation of NF-kappaB involves its release from IkappaB and subsequent nuclear… CONTINUE READING

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