Manufacturing recombinant adeno-associated viral vectors from producer cell clones.

@article{Thorne2009ManufacturingRA,
  title={Manufacturing recombinant adeno-associated viral vectors from producer cell clones.},
  author={B. A. Avril Thorne and Ryan K. Takeya and Richard W. Peluso},
  journal={Human gene therapy},
  year={2009},
  volume={20 7},
  pages={
          707-14
        }
}
A commercial rAAV manufacturing process needs to provide a safe product at high yield, be easily scalable, regulatory-compliant, and have reasonable cost of goods. Considerations for process development include not only product quantity and quality, but also ease of obtaining equipment, performing validation, and demonstrating control. In these regards, it is usually efficient to make use of proven technologies for more established areas of manufacturing, such as cell culture and purification… CONTINUE READING
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