Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations.

@article{Paudel2013ManufacturingOS,
  title={Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations.},
  author={Amrit Paudel and Zelalem Ayenew Worku and Joke Meeus and Sandra Guns and Guy Van den Mooter},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={453 1},
  pages={253-84}
}
Spray drying is an efficient technology for solid dispersion manufacturing since it allows extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to solid API-carrier particles. Solvent evaporation kinetics certainly contribute to formation of amorphous solid dispersions, but also other factors like the interplay between the API, carrier and solvent, the solution state of the API, formulation parameters (e.g. feed concentration or solvent type) and process… CONTINUE READING
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