Manufacturing Clinical Grade Recombinant Adeno-Associated Virus Using Invertebrate Cell Lines.

@article{Kotin2017ManufacturingCG,
  title={Manufacturing Clinical Grade Recombinant Adeno-Associated Virus Using Invertebrate Cell Lines.},
  author={Robert M. Kotin and Richard O. Snyder},
  journal={Human gene therapy},
  year={2017},
  volume={28 4},
  pages={350-360}
}
Recombinant adeno-associated virus (rAAV) vectors are proving to be a reliable gene transfer system for several clinical applications, with an increasing body of evidence supporting safety and efficacy. Realizing the clinical and commercial potential of rAAV depends on a reliable source of high-quality, well-characterized rAAV lots. This requirement has… CONTINUE READING