Manual versus automated γ-H2AX foci analysis across five European laboratories: can this assay be used for rapid biodosimetry in a large scale radiation accident?

@article{Rothkamm2013ManualVA,
  title={Manual versus automated γ-H2AX foci analysis across five European laboratories: can this assay be used for rapid biodosimetry in a large scale radiation accident?},
  author={Kai Rothkamm and Stephen GR Barnard and Elizabeth A. Ainsbury and J. Al-hafidh and J Barquinero and Carita Lindholm and Jayne E Moquet and Marjo Per{\"a}l{\"a} and Sandrine H Roch-Lef{\`e}vre and Harry Scherthan and Hubert Thierens and Anne Vral and Veerle Vandersickel},
  journal={Mutation research},
  year={2013},
  volume={756 1-2},
  pages={170-3}
}
The identification of severely exposed individuals and reassurance of the 'worried well' are of prime importance for initial triage following a large scale radiation accident. We aim to develop the γ-H2AX foci assay into a rapid biomarker tool for use in accidents. Here, five laboratories established a standard operating procedure and analysed 100 ex vivo γ-irradiated, 4 or 24h incubated and overnight-shipped lymphocyte samples from four donors to generate γ-H2AX reference data, using manual… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…