Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial

@article{Hovorka2010ManualCI,
  title={Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial},
  author={Roman Hovorka and Janet M. Allen and Daniela Elleri and Ludovic J. Chassin and Julie Harris and Dongyuan Xing and Craig R. Kollman and Tomas Hovorka and Anne Mette Foldager Larsen and Marianna Nodale and Alessandra De Palma and Malgorzata E. Wilinska and Carlo L Acerini and David B Dunger},
  journal={The Lancet},
  year={2010},
  volume={375},
  pages={743-751}
}
BACKGROUND Closed-loop systems link continuous glucose measurements to insulin delivery. We aimed to establish whether closed-loop insulin delivery could control overnight blood glucose in young people. METHODS We undertook three randomised crossover studies in 19 patients aged 5-18 years with type 1 diabetes of duration 6.4 years (SD 4.0). We compared standard continuous subcutaneous insulin infusion and closed-loop delivery (n=13; APCam01); closed-loop delivery after rapidly and slowly… CONTINUE READING
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