Mantle cell lymphoma: an update.

  title={Mantle cell lymphoma: an update.},
  author={Mark A. Raffeld and Christian A. Sander and Takahiro Yano and Elaine S. Jaffe},
  journal={Leukemia & lymphoma},
  volume={8 3},
Mantle cell lymphoma is a distinctive pathologic entity that incorporates the previous histopathologic categories of centrocytic lymphoma and lymphocytic lymphoma of intermediate differentiation. These lymphomas are characterized by common histologic and immunologic characteristics that suggest derivation from the follicular mantle zone. Mantle cell lymphomas are characterized by the t(11;14) (q13;q32) translocation and its molecular counterpart bcl-1 rearrangement. This translocation activates… CONTINUE READING