Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore

@article{Kuang2017MansouramycinCK,
  title={Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore},
  author={Shan Kuang and Ge Liu and Ruobing Cao and Linli Zhang and Q. Yu and C. Sun},
  journal={Oncotarget},
  year={2017},
  volume={8},
  pages={104057 - 104071}
}
Cancer is one of the deadliest diseases in the world and the search for novel anticancer agents is urgently required. Marine-derived isoquinolinequinones have exhibited promising anticancer activities. However, the exact mechanisms of cytotoxic activities of these isoquinolinequinones are poorly characterized. In this study, we investigated the anticancer effects and molecular mechanisms of mansouramycin C (Mm C), a cytotoxic isoquinolinequinone isolated from a marine streptomycete. We… Expand
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