Mannosylated cationic liposomes/CpG DNA complex for the treatment of hepatic metastasis after intravenous administration in mice.

@article{Kuramoto2009MannosylatedCL,
  title={Mannosylated cationic liposomes/CpG DNA complex for the treatment of hepatic metastasis after intravenous administration in mice.},
  author={Yukari Kuramoto and Shigeru Kawakami and Shuwen Zhou and Kyouichi Fukuda and Fumiyoshi Yamashita and Mitsuru Hashida},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 3},
  pages={
          1193-7
        }
}
Immunotherapy using immunostimulatory CpG DNA could be a promising new therapeutic approach to combat refractory hepatic metastasis. In this study, we report the use of a conventional cationic liposomes/CpG DNA complex (Bare/CpG DNA lipoplex) and a mannosylated cationic liposomes/CpG DNA complex (Man/CpG DNA lipoplex) for effective inhibition of hepatic metastasis in mice. After intravenous administration of Bare/CpG DNA lipoplex, higher amounts of IL-12 and IFN-gamma were produced in serum or… CONTINUE READING
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