Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.

@article{Lasala2003MannosylGS,
  title={Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.},
  author={F{\'a}tima Lasala and Eva Casas Arce and Joaqu{\'i}n R. Otero and Javier Rojo and Rafael Delgado},
  journal={Antimicrobial agents and chemotherapy},
  year={2003},
  volume={47 12},
  pages={3970-2}
}
We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection. 

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