Mannose receptor-mediated gene delivery into antigen presenting dendritic cells.

@article{Diebold2002MannoseRG,
  title={Mannose receptor-mediated gene delivery into antigen presenting dendritic cells.},
  author={Sandra S. Diebold and Christian Plank and Matt Cotten and Ernst Wagner and Martin Zenke},
  journal={Somatic cell and molecular genetics},
  year={2002},
  volume={27 1-6},
  pages={65-74}
}
Dendritic cells are professional antigen presenting cells and are unique in their ability to prime naïve T cells. Gene modification of dendritic cells is of particular interest for immunotherapy of diseases where the immune system has failed or is aberrantly regulated, such as in cancer or autoimmune disease, respectively. Dendritic cells abundantly express mannose receptor and mannose receptor-related receptors, and receptor-mediated gene transfer via mannose receptor offers a versatile tool… CONTINUE READING

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