Mannose-receptor-mediated clearance of lysosomal alpha-mannosidase in scavenger endothelium of cod endocardium.

@article{Srensen2001MannosereceptormediatedCO,
  title={Mannose-receptor-mediated clearance of lysosomal alpha-mannosidase in scavenger endothelium of cod endocardium.},
  author={Karen Kristine S{\o}rensen and Ole Kristian Tollersrud and Gry Evjen and B{\aa}rd H Smedsr{\o}d},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  year={2001},
  volume={129 2-3},
  pages={
          615-30
        }
}
Mannose-receptor-mediated clearance of circulating glycoproteins was studied in Atlantic cod (Gadus morhua). Distribution studies with radioiodinated and fluorescently labelled ligands showed that cod liver lysosomal alpha-mannosidase and yeast invertase were rapidly eliminated from blood via a mannose specific pathway in liver parenchymal cells and endocardial endothelial cells of atrium and ventricle. Asialo-orosomucoid, a galactose-terminated glycoprotein, was cleared by liver only. In vitro… CONTINUE READING
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