Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice.


Crescentic glomerulonephritis (CGN), which frequently results in acute and chronic kidney disease, is characterized by and dependent on glomerular infiltration by macrophages. The mannose receptor (MR) is a pattern recognition receptor implicated in the uptake of endogenous and microbial ligands by macrophages, mesangial cells (MCs), and selected… (More)
DOI: 10.1172/JCI41560

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