Mannose receptor and macrophage galactose‐type lectin are involved in Bordetella pertussis mast cell interaction

@article{Vukman2013MannoseRA,
  title={Mannose receptor and macrophage galactose‐type lectin are involved in Bordetella pertussis mast cell interaction},
  author={Krisztina V. Vukman and Alessandra Ravid{\'a} and Allison Aldridge and Sandra M. OˈNeill},
  journal={Journal of Leukocyte Biology},
  year={2013},
  volume={94}
}
Mast cells are crucial in the development of immunity against Bordetella pertussis, and the function of TLRs in this process has been investigated. Here, the interaction between mast cells and B. pertussis with an emphasis on the role of CLRs is examined. In this study, two CLRs, MGL and MR, were detected for the first time on the surface of mast cells. The involvement of MR and MGL in the stimulation of mast cells by heat‐inactivated BP was investigated by the use of blocking antibodies and… 

Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia

TLDR
Results show a previously undetermined role of MGL1 in controlling neutrophilia during pneumonic infection, thus playing an important role in resolution of inflammation.

The Macrophage Galactose-Type Lectin-1 (MGL1) Recognizes Taenia crassiceps Antigens, Triggers Intracellular Signaling, and Is Critical for Resistance to This Infection

TLDR
Flow cytometry and RT-PCR analyses showed overexpression of the mannose receptors, IL-4Rα, PDL2, arginase-1, Ym1, and RELM-α on MGL1−/− macrophages, which indicate that M GL1 is involved in T. crassiceps recognition and subsequent innate immune activation and resistance.

Role of the Mannose Receptor During Aspergillus fumigatus Infection and Interaction With Dectin-1 in Corneal Epithelial Cells

TLDR
Investigation of the expression and function of the mannose receptor and its interaction with dectin-1 in human corneal epithelial cells exposed to Aspergillus fumigatus found that HCECs express the MR, and A. fumigsatus infection can increase MR expression.

Human macrophage polarization shapes B. pertussis intracellular persistence

TLDR
Intracellular B. pertussis is able to survive regardless of the macrophage activation program, but its intracellular survival proved higher in M2 compared with the M1 macrophages, being M2c the best candidate to develop into a niche of persistence for B.pertussis.

An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides

TLDR
v6D is a functional ligand for CLEC10A and induces maturation of immune cells in the peritoneal cavity and caused a highly significant extension of survival of mice with implanted ovarian cancer cells with a favorable toxicity and non-antigenic profile.

Fasciola hepatica Immune Regulates CD11c+ Cells by Interacting with the Macrophage Gal/GalNAc Lectin

TLDR
A potential role of MGL in the immunomodulation of DCs induced by F. hepatica is suggested and this work identified MGL-expressing CD11c+ cells in infected animals and showed that these cells are recruited both to the peritoneum and the liver upon F. liveratica infection.

An overview of mast cell pattern recognition receptors

TLDR
This review will focus on the current knowledge of PRRs expressed within different types of MCs, which include Toll-like receptors activated by different pathogen- and damage-associated molecular patterns, and RIG- like receptors relevant in viral sensing.

Regulation of the pleiotropic effects of tissue-resident mast cells.

References

SHOWING 1-10 OF 70 REFERENCES

Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin

TLDR
It is shown that Bordetella pertussis can adhere to and be phagocytosed by mast cells, and mast cells are able to process and present B. pertussi antigens to T lymphocytes, suggesting that mast cells may play a role in the induction of immune responses against B.pertussis through the release of cytokines.

Diverse effects of bacterial cell wall components on mast cell degranulation, cysteinyl leukotriene generation and migration

TLDR
The results show that PGN, LPS and LAM might be among the important bacterial antigens involved in mast cell activation during bacterial infection.

Influence of the mannose receptor in host immune responses.

Characterization of Mannose Receptor-Dependent Phagocytosis Mediated by Mycobacterium tuberculosisLipoarabinomannan

TLDR
The terminal mannosyl units of the M. tuberculosis surface lipoglycan, lipoarabinomannan (LAM), from the Erdman strain serve as ligands for the MR, and the requirements for macrophage phagocytosis of a LAM-coated particle mediated by the MR are characterized.

Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands

TLDR
It is shown that murine mature connective tissue‐type MCs, but not immature bone marrow‐derived cultured mast cells, express significant amounts of full length TLR2 on their surface, suggesting that tissue‐residing cells, which most likely occurs during infection, can selectively raise a potent inflammatory or anti‐inflammatory response, depending on TLRs which are engaged.

A new member of the C-type lectin family is a modulator of the mast cell secretory response.

TLDR
Though no ligand has yet been identified for the MAFA, experiments using antisense oligonucleotides suggest that this novel lectin may have a role in cell adhesion in addition to its immunomodulatory capacity.

Role of sugars in surface microbe-host interactions and immune reaction modulation.

TLDR
A promising approach is the use of a panel of carbohydrate derivatives with anti-adhesive efficacy against bacteria frequently involved in diseases affecting skin and other epithelia.

Fasciola hepatica Tegumental Coat Impairs Mast Cells’ Ability To Drive Th1 Immune Responses

TLDR
It is shown that FhTeg inhibits the ability of mast cells to drive the Th1 immune response by suppressing cytokine secretion and ICAM1 expression in mast cells stimulated with LPS or heat-inactivated Bordetella pertussis Ag, and a role forICAM1 in this process was demonstrated.

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans1

TLDR
Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans.
...