Mannose metabolism is required for mycobacterial growth.

  title={Mannose metabolism is required for mycobacterial growth.},
  author={J. H. Patterson and Ross Frederick Waller and Dharshini Jeevarajah and Helen Billman-Jacobe and Malcolm J. McConville},
  journal={The Biochemical journal},
  volume={372 Pt 1},
Mycobacteria are the causative agents of tuberculosis and several other significant diseases in humans. All species of mycobacteria synthesize abundant cell-wall mannolipids (phosphatidylinositol mannosides, lipoarabinomannan), a cytoplasmic methylmannose polysaccharide and O-mannosylated glycoproteins. To investigate whether these molecules are essential for mycobacterial growth, we have generated a Mycobacterium smegmatis mannose auxotroph by targeted deletion of the gene encoding… CONTINUE READING
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