Mannose metabolism is required for mycobacterial growth.

@article{Patterson2003MannoseMI,
  title={Mannose metabolism is required for mycobacterial growth.},
  author={J. H. Patterson and Ross Frederick Waller and Dharshini Jeevarajah and Helen Billman-Jacobe and Malcolm J. McConville},
  journal={The Biochemical journal},
  year={2003},
  volume={372 Pt 1},
  pages={
          77-86
        }
}
Mycobacteria are the causative agents of tuberculosis and several other significant diseases in humans. All species of mycobacteria synthesize abundant cell-wall mannolipids (phosphatidylinositol mannosides, lipoarabinomannan), a cytoplasmic methylmannose polysaccharide and O-mannosylated glycoproteins. To investigate whether these molecules are essential for mycobacterial growth, we have generated a Mycobacterium smegmatis mannose auxotroph by targeted deletion of the gene encoding… CONTINUE READING
Highly Cited
This paper has 25 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Lipoglycans Contribute to Innate Immune Detection of Mycobacteria

PloS one • 2011
View 9 Excerpts
Method Support
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 42 references

The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence

R. J. Henry, A. B. Blakeney, P. J. Harris, B. A. Stone
J . Biol . Chem . • 2001

The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan

N. M. Parrish, T. Houston, P. B. Jones, C. Townsend, J. D. Dick
J . Biol . Chem . • 2001