Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation.

@article{Mullighan2008MannosebindingLS,
  title={Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation.},
  author={Charles G Mullighan and S L Heatley and Silke Danner and Melinda M. Dean and Kathleen T. Doherty and Uwe Hahn and Kenneth F. Bradstock and Robyn M Minchinton and Anthony P. Schwarer and Jeff Szer and Peter G. Bardy},
  journal={Blood},
  year={2008},
  volume={112 5},
  pages={
          2120-8
        }
}
Mannose-binding lectin (MBL) is a mediator of innate immunity that influences the risk of infection in a range of clinical settings. We previously reported associations between MBL2 genotype and infection in a retrospective study of myeloablative allogeneic hematopoietic stem cell transplantation (allo-HCT). However, other studies have been inconclusive, and the role of MBL in reduced-intensity conditioning (RIC) transplantation is unknown. Here we report a prospective study examining MBL2… CONTINUE READING
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