Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus.

@article{Garred1999MannosebindingLP,
  title={Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus.},
  author={Peter Garred and Hans Ole Madsen and Poul Halberg and J\orgen Petersen and Gitte Kronborg and Arne Svejgaard and Vagn Andersen and S. -E. Jacobsen},
  journal={Arthritis and rheumatism},
  year={1999},
  volume={42 10},
  pages={2145-52}
}
OBJECTIVE To determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections. METHODS MBL alleles and serum concentrations were determined by polymerase chain reaction and enzyme-linked immunosorbent assay, respectively, in 91 Danish patients with SLE and in 250 controls. RESULTS Homozygosity for MBL variant alleles was observed in 7.7% of the SLE… CONTINUE READING