Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis.


Classical complement pathway factor, C4 is required for experimental autoimmune myasthenia gravis (EAMG) pathogenesis. C4 is also a central component of the mannose binding lectin (MBL) pathway suggesting that this pathway might also be involved in MG pathogenesis. However, MBL gene deficient mice displayed intact anti-acetylcholine receptor (AChR)-immune response and neuromuscular junction (NMJ) IgG and complement accumulation following AChR-immunization. Moreover, no significant difference was observed between the serum MBL levels of 77 anti-AChR antibody positive generalized MG patients and 105 healthy controls. Therefore, MBL pathway does not play a role in EAMG/MG pathogenesis.

DOI: 10.1016/j.jneuroim.2008.12.013

Cite this paper

@article{Li2009MannosebindingLP, title={Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis.}, author={Jing Li and Huibin Qi and Erdem T{\"{u}z{\"{u}n and Windy R Allman and Vuslat Yilmaz and Shamsher S. Saini and Feza Deymeer and G Saruhan-Direskeneli and Premkumar Christadoss}, journal={Journal of neuroimmunology}, year={2009}, volume={208 1-2}, pages={40-5} }