Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages.

@article{Jack2005MannosebindingLE,
  title={Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages.},
  author={Dominic L. Jack and Margaret E. Lee and Malcolm W. Turner and Nigel Klein and Robert C Read},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={77 3},
  pages={328-36}
}
Deficiency of mannose-binding lectin (MBL) is probably the most common human immunodeficiency and is associated with an increased risk of mucosally acquired infections including meningococcal disease. Tissue macrophages are an important component of mucosal defense, and so we determined the effect of MBL on uptake of meningococci by human monocyte-derived macrophages. Opsonization with MBL significantly increased the capture and doubled the amount of internalization of Neisseria meningitidis… CONTINUE READING