Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis.

@article{Bonte2012MannosebindingLS,
  title={Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis.},
  author={Laura R. La Bonte and Vasile I. Pavlov and Ying Siow Tan and Kazue Takahashi and Minoru Takahashi and Nirmal K Banda and Chenhui Zou and Teizo Fujita and Gregory L Stahl},
  journal={Journal of immunology},
  year={2012},
  volume={188 2},
  pages={885-91}
}
Bleeding disorders and thrombotic complications constitute a major cause of death and disability worldwide. Although it is known that the complement and coagulation systems interact, no studies have investigated the specific role or mechanisms of lectin-mediated coagulation in vivo. FeCl(3) treatment resulted in intra-arterial occlusive thrombogenesis within 10 min in wild-type (WT) and C2/factor B-null mice. In contrast, mannose-binding lectin (MBL)-null and MBL-associated serine protease… CONTINUE READING
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