Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction.

@article{Sziller2007MannosebindingL,
  title={Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction.},
  author={Istv{\'a}n Sziller and Oksana Babula and Petronella Hupuczi and B{\'a}lint Nagy and Barbara Rig{\'o} and G{\'a}bor Szab{\'o} and Zsuzsanna Reed Papp and Iara Moreno Linhares and Steven S Witkin},
  journal={Molecular human reproduction},
  year={2007},
  volume={13 4},
  pages={
          281-5
        }
}
Insufficient invasion of the spiral arteries by trophoblast cells is associated with the etiology of pre-eclampsia, the syndrome of hemolysis, elevated liver enzymes and low platelet counts (HELLP) and pre-eclampsia-associated intrauterine growth restriction (IUGR). Mannose-binding lectin (MBL) is a component of the innate immune system. MBL-mediated activation of the complement cascade is an important event in the destruction of invading trophoblasts. The gene coding for MBL is polymorphic… CONTINUE READING

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Pre-eclampsia: the death of Goliath

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