Mannose-based molecular patterns on stealth microspheres for receptor-specific targeting of human antigen-presenting cells.

@article{Wattendorf2008MannosebasedMP,
  title={Mannose-based molecular patterns on stealth microspheres for receptor-specific targeting of human antigen-presenting cells.},
  author={Uta Wattendorf and G{\'e}raldine Coullerez and J{\'a}nos V{\"o}r{\"o}s and Marcus Textor and Hans Peter Merkle},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2008},
  volume={24 20},
  pages={
          11790-802
        }
}
The targeting of antigen-presenting cells has recently gained strong attention for both targeted vaccine delivery and immunomodulation. We prepared surface-modified stealth microspheres that display various mannose-based ligands at graded ligand densities to target phagocytic C-type lectin receptors (CLRs) on human dendritic cells (DCs) and macrophages. Decoration of microspheres with carbohydrate ligands was achieved (i) by electrostatic surface assembly of mannan onto previously formed… CONTINUE READING

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