Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis

@article{Lee2002MannoseRR,
  title={Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis},
  author={Sena J Lee and Stefan Evers and D Roeder and Albert F. Parlow and Juha P Risteli and Leila Risteli and Y. C. Lee and Ten Feizi and Hanno Langen and Michel C. Nussenzweig},
  journal={Science},
  year={2002},
  volume={295},
  pages={1898 - 1901}
}
Carbohydrates are thought to function as tags that mark circulatory glycoproteins for rapid clearance. To examine the role of the mannose receptor (MR) in glycoprotein clearance, we generated mice genetically deficient in MR. MR−/− mice were defective in clearing proteins bearing accessible mannose andN-acetylglucosamine residues and had elevated levels of eight different lysosomal hydrolases. Proteomic analysis of MR−/− and control mouse sera showed that an additional 4 out of 52 proteins… Expand
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