Mannose Inhibits Hyaluronan Synthesis by Down-regulation of the Cellular Pool of UDP-N-acetylhexosamines*

  title={Mannose Inhibits Hyaluronan Synthesis by Down-regulation of the Cellular Pool of UDP-N-acetylhexosamines*},
  author={T. Jokela and M. Jauhiainen and S. Auriola and Miia Kauhanen and R. Tiihonen and M. Tammi and R. Tammi},
  journal={Journal of Biological Chemistry},
  pages={7666 - 7673}
  • T. Jokela, M. Jauhiainen, +4 authors R. Tammi
  • Published 2008
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • We found that d-mannose dose-dependently decreases hyaluronan synthesis in cultured epidermal keratinocytes to ∼50%, whereas glucose, galactose, and fructose up to 20 mm concentration had no effect. The full inhibition occurred within 3 h following introduction of mannose and did not involve down-regulation of hyaluronan synthase (Has1–3) mRNA. Following introduction of mannose, there was an ∼50% reduction in the cellular concentration of UDP-N-acetylhexosamines (UDP-HexNAc, i.e. UDP-N… CONTINUE READING
    51 Citations
    Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3*
    • 77
    • PDF
    Role of UDP-N-Acetylglucosamine (GlcNAc) and O-GlcNAcylation of Hyaluronan Synthase 2 in the Control of Chondroitin Sulfate and Hyaluronan Synthesis*
    • 89
    • PDF
    UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression
    • 32
    The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.
    • V. Hascall, A. Wang, +6 authors G. Hart
    • Biology, Medicine
    • Matrix biology : journal of the International Society for Matrix Biology
    • 2014
    • 67
    • PDF
    The effects of 4-methylumbelliferone on hyaluronan synthesis, MMP2 activity, proliferation, and motility of human aortic smooth muscle cells.
    • 70
    • Highly Influenced
    • PDF


    UDP-sugar metabolism in Swarm rat chondrosarcoma chondrocytes.
    • 44
    A Novel Mechanism for the Inhibition of Hyaluronan Biosynthesis by 4-Methylumbelliferone*
    • 197
    • PDF