Mannose Inhibits Hyaluronan Synthesis by Down-regulation of the Cellular Pool of UDP-N-acetylhexosamines*

@article{Jokela2008MannoseIH,
  title={Mannose Inhibits Hyaluronan Synthesis by Down-regulation of the Cellular Pool of UDP-N-acetylhexosamines*},
  author={Tiina A. Jokela and Marjo Jauhiainen and Seppo O K Auriola and Miia Kauhanen and Riikka Tiihonen and Markku I. Tammi and Raija H. Tammi},
  journal={Journal of Biological Chemistry},
  year={2008},
  volume={283},
  pages={7666 - 7673}
}
We found that d-mannose dose-dependently decreases hyaluronan synthesis in cultured epidermal keratinocytes to ∼50%, whereas glucose, galactose, and fructose up to 20 mm concentration had no effect. The full inhibition occurred within 3 h following introduction of mannose and did not involve down-regulation of hyaluronan synthase (Has1–3) mRNA. Following introduction of mannose, there was an ∼50% reduction in the cellular concentration of UDP-N-acetylhexosamines (UDP-HexNAc, i.e. UDP-N… Expand
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TLDR
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1-Ethyl-β-N-acetylglucosaminide increases hyaluronan production in human keratinocytes by being converted to N-acetylglucosamine via β-N-acetylglucosaminidase-dependent manner.
TLDR
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The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.
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  • Matrix biology : journal of the International Society for Matrix Biology
  • 2014
TLDR
Some data are outlined that support a model that hyaluronan metabolism can be a rheostat for controlling an acceptable normal range of cytosolic UDP-GlcNAc concentrations in order to maintain normal cell functions. Expand
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TLDR
The effects on SMC behavior of 4-methylumbelliferone are assessed, showing that 4-MU strongly inhibits AoSMCs migration, which was restored by the addition of exogenous HA indicating that the rescuing depends on the interaction of HA with its receptor CD44. Expand
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