Mannose Inhibits Hyaluronan Synthesis by Down-regulation of the Cellular Pool of UDP-N-acetylhexosamines*

@article{Jokela2008MannoseIH,
  title={Mannose Inhibits Hyaluronan Synthesis by Down-regulation of the Cellular Pool of UDP-N-acetylhexosamines*},
  author={T. Jokela and M. Jauhiainen and S. Auriola and Miia Kauhanen and R. Tiihonen and M. Tammi and R. Tammi},
  journal={Journal of Biological Chemistry},
  year={2008},
  volume={283},
  pages={7666 - 7673}
}
  • T. Jokela, M. Jauhiainen, +4 authors R. Tammi
  • Published 2008
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • We found that d-mannose dose-dependently decreases hyaluronan synthesis in cultured epidermal keratinocytes to ∼50%, whereas glucose, galactose, and fructose up to 20 mm concentration had no effect. The full inhibition occurred within 3 h following introduction of mannose and did not involve down-regulation of hyaluronan synthase (Has1–3) mRNA. Following introduction of mannose, there was an ∼50% reduction in the cellular concentration of UDP-N-acetylhexosamines (UDP-HexNAc, i.e. UDP-N… CONTINUE READING
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