Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells.

@article{Kesteren1997Mannose6R,
  title={Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells.},
  author={Charlotte van Kesteren and A. H. Jan Danser and Frans H. M. Derkx and Dick H. W. Dekkers and Jos M. J. Lamers and Pramod R. Saxena and Maarten A. D. H. Schalekamp},
  journal={Hypertension},
  year={1997},
  volume={30 6},
  pages={1389-96}
}
The binding and internalization of recombinant human renin and prorenin (2500 microU/mL) and the activation of prorenin were studied in neonatal rat cardiac myocytes and fibroblasts cultured in a chemically defined medium. Surface-bound and internalized enzymes were distinguished by the addition of mannose 6-phosphate to the medium, by incubating the cells both at 37 degrees C and 4 degrees C, and by the acid-wash method. Mannose 6-phosphate inhibited the binding of renin and prorenin to the… CONTINUE READING

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