Corpus ID: 24864248

Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Further evidence for a role for inositol phosphate-oligosaccharides in insulin action.

@article{Machicao1990MannoseGA,
  title={Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Further evidence for a role for inositol phosphate-oligosaccharides in insulin action.},
  author={Fausto Machicao and Joanne Mushack and E. Seffer and Brian F. Ermel and H. U. H{\"a}ring},
  journal={The Biochemical journal},
  year={1990},
  volume={266 3},
  pages={
          909-16
        }
}
The mechanism of insulin signalling is not yet understood in detail. Recently, a role for inositol phosphate (IP)-oligosaccharides as second messengers transmitting the insulin signal at the post-kinase level was proposed. To evaluate this hypothesis further, we studied whether IP-oligosaccharides isolated from 'haemodialysate' have insulin-like activity. We found that these compounds mimic, in a dose-dependent fashion, the following effects of insulin in adipocytes. (1) Lipogenesis… Expand
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  • 1997
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