Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion.

@article{Khoury2010MannitolAK,
  title={Mannitol attenuates kidney damage induced by xanthine oxidase-associated pancreas ischemia-reperfusion.},
  author={Wisam Khoury and Michael Namnesnikov and Dimitri Fedorov and Samir Abu-Gazala and Avi A. Weinbroum},
  journal={The Journal of surgical research},
  year={2010},
  volume={160 1},
  pages={
          163-8
        }
}
BACKGROUND Ischemia and subsequent reperfusion (IR) may induce local and remote organ reperfusion injury. It may be propagated by xanthine oxidase (XO)-generated oxidant stress. We investigated whether pancreas IR directly and acutely induces renal dysfunction and if this outcome could be prevented by mannitol. MATERIALS AND METHODS Rat pancreases were isolated and perfused with Krebs-Henseleit solution enriched with 5% bovine albumin. Other rats donated kidneys that were perfused at constant… CONTINUE READING
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