Mannan-binding lectin mediates renal ischemia/reperfusion injury independent of complement activation.

@article{Pol2012MannanbindingLM,
  title={Mannan-binding lectin mediates renal ischemia/reperfusion injury independent of complement activation.},
  author={Pieter van der Pol and Nicole Schlagwein and Danielle J van Gijlswijk and Stefan Perkmann Berger and Anja Roos and Ingeborg M. Bajema and Hetty C. de Boer and Johan W. de Fijter and Gregory L Stahl and Mohamed R. Daha and Cees van Kooten},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2012},
  volume={12 4},
  pages={877-87}
}
Ischemia/reperfusion injury (IRI) remains a major problem in renal transplantation. Clinical studies have identified that high serum levels of Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, are associated with inferior renal allograft survival. Using a rat model, we identified an entirely novel role for MBL in mediating renal IRI. Therapeutic inhibition of MBL was protective against kidney dysfunction, tubular damage, neutrophil and macrophage… CONTINUE READING