Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.

@article{Degn2012MannanbindingLS,
  title={Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.},
  author={S\oren E. Degn and Lisbeth Jensen and Annette G. Hansen and Duygu Duman and Mustafa Tekin and Jens Christian Jensenius and Steffen Thiel},
  journal={Journal of immunology},
  year={2012},
  volume={189 8},
  pages={3957-69}
}
The lectin pathway of complement is an important component of innate immunity. Its activation has been thought to occur via recognition of pathogens by mannan-binding lectin (MBL) or ficolins in complex with MBL-associated serine protease (MASP)-2, followed by MASP-2 autoactivation and cleavage of C4 and C2 generating the C3 convertase. MASP-1 and MASP-3 are related proteases found in similar complexes. MASP-1 has been shown to aid MASP-2 convertase generation by auxiliary C2 cleavage. In mice… CONTINUE READING
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