Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus.

@article{Saevarsdttir2006MannanbindingLA,
  title={Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus.},
  author={Saed{\'i}s Saevarsd{\'o}ttir and Helga Kristj{\'a}nsd{\'o}ttir and Gerdur Grondal and Th V{\'i}kingsd{\'o}ttir and Kristj{\'a}n Steinsson and Helgi Valdimarsson},
  journal={Annals of the rheumatic diseases},
  year={2006},
  volume={65 11},
  pages={1462-7}
}
OBJECTIVE To determine whether low mannan-binding lectin (MBL) and C4A null alleles (C4AQ0) are associated with systemic lupus erythematosus (SLE) in multicase families with SLE. METHODS Low MBL level was determined by measuring serum levels and by genotyping for mutant structural (B/C/D, designated as 0) and promoter (LX) alleles (by real-time polymerase chain reaction). C4AQ0 was detected by protein electrophoresis and corroborated with haplotype and genotype analysis. In nine Icelandic… CONTINUE READING

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