Mannan-binding lectin: clinical significance and applications.

  title={Mannan-binding lectin: clinical significance and applications.},
  author={David Chalmers Kilpatrick},
  journal={Biochimica et biophysica acta},
  volume={1572 2-3},
Mannan-binding lectin (MBL) is a collectin (protein with both collagen-like and C-type lectin domains) synthesised in the liver and secreted into the bloodstream. Its plasma concentration is for the most part genetically determined by a series of allelic dimorphisms located both in the structural gene and in the promoter region. Genotypes made up of combinations of seven haplotypes are mainly responsible for a 1000-fold concentration variation found in human beings. MBL is a pattern recognition… CONTINUE READING

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