Manipulations of metallothionein gene dose accelerate the response to Listeria monocytogenes.

@article{Emeny2009ManipulationsOM,
  title={Manipulations of metallothionein gene dose accelerate the response to Listeria monocytogenes.},
  author={Rebecca T Emeny and Gregory Marusov and David S Lawrence and Joan Pederson-Lane and Xiuyun Yin and Michael A. Lynes},
  journal={Chemico-biological interactions},
  year={2009},
  volume={181 2},
  pages={243-53}
}
Metallothioneins (MTs) are cysteine-rich proteins that assist in cellular homeostasis and protect against oxidant injury. MTs can be induced by heavy metals and inflammatory mediators and function as free radical scavengers, reservoirs for essential heavy metals, and immunomodulators. In light of MTs' roles in responses to stress, we evaluated the in vivo effects of MT gene dose on the course of Listeria monocytogenes (LM) infection. LM burden was measured in livers and spleens, and flow… CONTINUE READING
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