Manipulations During the Second, but not the First, Week of Life Increase Susceptibility to Cocaine Self-Administration in Female Rats

@article{Flagel2003ManipulationsDT,
  title={Manipulations During the Second, but not the First, Week of Life Increase Susceptibility to Cocaine Self-Administration in Female Rats},
  author={Shelly B. Flagel and Delia Vazquez and Terry E. Robinson},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={1741-1751}
}
We compared the effects of manipulations during week 1 vs week 2 of life on the propensity to self-administer cocaine. Pups received daily subcutaneous saline injections, were handled briefly, or remained undisturbed during their respective treatment periods. Animals handled during the second week of life exhibited increased locomotor response to novelty when tested on postnatal day (PND) 48, compared to all other groups. Rats were implanted with jugular catheters on PND 70 and then given the… CONTINUE READING

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