Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification

@inproceedings{Rodriguez2014ManipulationOV,
  title={Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification},
  author={Karien J Rodriguez and Laura M Piechura and Ana M. Porras and Kristyn S. Masters},
  booktitle={BMC cardiovascular disorders},
  year={2014}
}
BACKGROUND Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen attenuates the responsiveness of VICs to pro-calcific stimuli. The current study uses… CONTINUE READING
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