Manipulation of thrombus formation in the hamster cheek pouch with drugs that interact with PGI2 in vitro.

@article{Shishido1982ManipulationOT,
  title={Manipulation of thrombus formation in the hamster cheek pouch with drugs that interact with PGI2 in vitro.},
  author={M. Shishido and R. Hirose and K. Tanaka and M. Katori},
  journal={Prostaglandins},
  year={1982},
  volume={23 6},
  pages={
          907-17
        }
}
A single platelet thrombus was formed in an arteriole of the hamster cheek pouch by electrical stimulation followed by topical application of ADP. The sizes of the thrombi were continuously recorded with a photocell placed on a TV monitor screen and quantified by areas on the record. Repeated application of small doses of ADP (5-15 nmole/10 microliters) resulted in very reproducible formation of the thrombi, and the size of the thrombi was reduced dose-dependently by topical application of PGI2… Expand
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